Second Global School of Translational Science

The Second Global School of Translational Science is driven by the study of diseases whose incidence rose dramatically with the increase in the life expectancy of the population. Cancer and neurodegenerative conditions, such as Alzheimer's Disease, Parkinson's Disease, Amyotrophic Lateral Sclerosis and diseases caused by prions, still incurable, represent a major problem for society and should drain a lot of resources over the next 20 years.

The goal of the school is to provide a setting for discussion of molecular medicine, from basics to translational aspects, both in cancer and in neurodegenerative diseases. The program has added some of the leading experts in the field of basic research and treatment, in an environment that favors learning and exchange of cutting-edge information in the area.

  • Institution

    Hospital A C Camargo. Fundação Antonio Prudente

  • Field of Knowledge


  • Academic Director

    Vilma Regina Martins

  • Grant Number


  • Date

    2011-06-19 to 2011-06-24

  • Registration Deadline


  • Site

  • City

    São Paulo

  • Keywords

    Cancer, pain, memory

  • Program Hide


    Organizing Committee

    Vilma R. Martins - A.C. Camargo Hospital, São Paulo, Brazil

    Marco A.M. Prado- Robarts Research Institute and University of Western Ontario, Ontario, Canada

    Glaucia Hajj - A.C. Camargo Hospital, São Paulo, Brazil

    Sergio Ferreira- Federal University of Rio de Janeiro, Rio de Janeiro

    Stephen Ferguson- Robarts Research Institute and University of Western Ontario, Ontario, Canada

    Marc G. Caron - Duke University Medical Center, Durham, North Caroline, USA


    June 19th - Day 1 

    9:30- 9:45Vilma R. Martins & Marco Antonio M. Prado

    Opening remarks

    9:45- 10:15 –Carlos Henrique de Brito Cruz

    Introducing FAPESP

    10:15- 10:45 - Ricardo R. Brentani

    Introducing the AC Camargo Hospital and the National Institutes of Science and technology

    11:00 – 12:00

    Opening conferenceDon Cleveland (University of California USCF / Ludwig Institute for Cancer Research)

    Guarding the genome: aneuploidy and tumorigenesis

    12:00 – 14:00 - Lunch 

    Membrane and cell signaling compartmentalization

    14:00 – 15:00   Jay T Groves (University of California/ HHMI)

    Mechanisms of signal transduction in cell membranes

    15:00- 16:00   John D Scott (Washington School of Medicine/HHMI)

    Cell Signaling in Space and Time

     16:00 - 16:30 Coffee break 

    16:30 - 17:30 – Marc Caron (Duke University)

    Brain Monoamines/GPCR Systems: New approaches for CNS disorder therapies?

    18:00 – 20:00 - Welcome Cocktail


    June 20th - Day 2 

    Molecular Mechanisms in pain 

    8:30-9:30 - Michael Salter (SickKids Research Institute)

    Exploring neuron-microglia signaling in pain plasticity 

    9:30-10:30 - Terrance Snutch (Brain Research Centre, Canada)

    Novel agents targeting voltage-gated calcium and sodium channels for pain intervention

    10:30-11:00 - Coffee break

    11:00-12:00- Marcus Vinicius Gomez (Federal University of Minas Gerais, Brazil)

    Brazilian toxins targeting channels involved in pain  

    12:00 – 14:00 - Lunch 

    Brain, development and Synaptic Plasticity

    14:00-15:00 - Roberto Lent (Federal University of Rio de Janeiro, Brazil)

    Developmental plasticity in the cerebral cortex of mice and men

    15:00 – 16:00 - John MacDonald (Robarts Research Institute, Canada)

    TRPing from NMDA receptors to Stroke and Alzheimer’s Dementia: Dysregulation of non-selective cation channels and changes in excitatory synaptic transmission in the hippocampus. 

    16:00 – 16:30  - Coffee break

    16:30- 17:30  Student presentation

    17:30-18:30  Meet the expert Happy hour  (The idea of these meetings is o give a more informal atmosphere for students to talk with the invited speakers).


    June 21th day 03 

    Genome and transcriptome 

    8:30-9:30 - Silvia Rogatto (A.C.  Camargo Hospital)

    Molecular approaches to identify biological markers of response to chemotherapy in cancer patients.

    9:30-10:30 – Dirce M Carraro  (A.C.  Camargo Hospital)

    Deciphering the transcriptome of breast cancer

    10:30-11:00 -   Coffee break

    11:00- 12:00 Emmanuel  Dias-Neto (A.C.  Camargo Hospital)

    miRNA regulatory networks 

    12:00-14:00 - Lunch 

    Drug discovery in diseases  

    14:00-15:00 – Robert Hegele (Robarts Research Institute, Canada)

    Genomic architecture of complex human metabolic disease

    15:00-16:00 – Elena Pasquale (Stanford-Burnham Medical Research Institute)

    Emerging Strategies to Target the Eph Receptor Family of Receptor Tyrosine Kinases for Disease Therapy

    16:00-16:30  - Coffee break

    16:30- 17:30 – Guido J.R. Zaman (Merck, Sharp & Dohme)

    Drug Discovery process in general (assay development, high-throughput screening, structural biology and lead optimization).

     17:30- 18:30 – Meet the expert Happy hour


    June 22rd  - Day 4 

    Cellular signaling in brain development and cognition 

    8:30- 9:30 - Martin Cammarota (Catholic University of Rio Grande do Sul, Brazil)

    On dopamine, BDNF and retrieval...and other factors controlling memory persistence

    9:30- 10:30 - Ivan Izquierdo (Catholic University of Rio Grande do Sul, Brazil)

     Why some consolidated memories last for a couple of days and others last for a lifetime

    10:30 -11:00 – Coffee break and poster

    11:00-12:00 - Eric Klann (New York University Center for Neural Science)

    Translational control: Molecules, synapses, behavior, and neurological disorders

    12:00-14:00 – Lunch 

    Cellular signaling and Neurotransmitter systems 

    14:00-15:00 - Vania Prado (Robarts Research Institute, Canada)

    Mouse models of cholinergic hypofunction: novel tales of an old neurotransmitter

    15:00-16:00 - Fernando Mello (Federal University of Rio de Janeiro, Brazil)

    Müller cells in identity crisis: To be or not to be a dopaminergic neuron

    16:00-16:30 – Coffee break and poster

    16:30-17:30- Esper Cavalheiro (Federal University of São Paulo)

    Epileptogenesis and antiepileptogenesis: an experimental approach

    17:30- 18:30 - Meet the expert -Happy hour

    (The idea of these meetings is o give a more informal atmosphere for students to talk with the invited speakers).


    June 23rd-5 day 

    Molecular pathology and new therapeutic candidates        

    8:30- 9:30 – Fernando A. Soares (A.C.  Camargo Hospital)  

    Connecting traditional morphology with molecular pathology: the pathway to new tumor classification

    9:30-10:30 – Vilma R. Martins (A.C.  Camargo Hospital)

    Prion protein signaling in Glioblastomas: a new therapeutic approach?

    10:30 -11:00       Coffee break

    11:00-12:00 – Rafael Linden (Federal University of Rio de Janeiro, Brazil)

    Subcellular localization of transcription factors: Target for neuroprotective gene therapy and implications for Neurosciences and Oncology 

    12:00-14:00 - Lunch 

    Post translational modifications and cellular stress

    14:00-15:00 - Ronald Hay (University of Dundee, UK)

    Molecular basis for arsenic trioxide therapy in Acute Promyelocytic Leukemia

    15:00-16:00 - Bradly Wouters (University Heath Network, Toronto)

    Cellular responses to the tumor microenvironment and their importance in cancer

    16:00-16:30 Coffee break

    16:30-17:30 Gabriela Chiosis (Memorial Sloan-Kettering Cancer Center)

    Modulation of heat shock proteins as a therapeutic approach in cancer and neurodegenerative diseases

     17:30-18:30 Selected student presentation


    June 24th - Day 6

    Neurodegenerative diseases 

    8:30- 9:30 - William Klein (Northwestern University, Illinois)

    Molecular basis for the cause, diagnosis and treatment of Alzheimer’s disease

    9:30- 10:30 - Marco Prado (Robarts Research Institute, Canada)

    STI1-Prion protein complex as a potential target in Alzheimer’s and Prion diseases

    10:30 -11:00 – Coffee break

    11:00 – 12:00 – Sergio Ferreira (Federal University of Rio de Janeiro, Brazil)

    Aβ oligomers, synaptic plasticity and mechanisms of pathogenesis in Alzheimer’s disease

    12:00-14:00 - Lunch 

    Neurodegenerative/neurological diseases

    14:00-15:00 - Glaucia Hajj (A. C. Camargo Hospital)

    The control of protein synthesis in Prion and Alzheimer Diseases

    15:00-16:00 - Stephen Ferguson (Robarts Research Institute, Canada)

    Role of Desensitization and Endocytosis in the Regulation of G protein-coupled Receptor Signaling in neurodegenerative and neuropsychiatric diseases

    16:00-16:30 – Coffee break

    Closing lecture

    16:30-17:30- Don Cleveland (University of California USCF/Ludwig Institute for Cancer Research)

    From Charcot to Lou Gehrig: mechanisms and therapy in Amyotrophic Lateral Sclerosis

    17:30-18:00 Closing remarks

    20:00     Farewell dinner