1st São Paulo School of Translational Science

The 1st São Paulo School of Translational Science was held by the Hospital AC Camargo with support of FAPESP, bringing together 40 researchers from eight countries to discuss, from the perspective of translational medicine, issues such as drug development, genomics, immunology, neuroscience and cancer. Translational Medicine is a branch of medical research that seeks to connect directly the scientific research to the treatment of patients. As predicted, 100 selected students received scholarships and support for transportation, lodging and meals. The speakers invited to the course were from over 20 of the leading universities in the United States, Canada, France, Italy, Sweden, Portugal, Argentina and Brazil. The participation of renowned researchers secured the visibility for the event-as well as the theme itself, since Translational Science approximates the basic science to clinical application.
  • Institution

    Hospital A C Camargo. Fundação Antonio Prudente

  • Field of Knowledge


  • Academic Director

    Emmanuel Dias-Neto

  • Grant Number


  • Date

    2010-04-19 to 2010-04-30

  • Registration Deadline


  • Site

  • City

    São Paulo

  • Keywords

    Neuroscience, Translational science, Cancer, Angiogenesis, Metastasis, Genomics

  • Program Hide

    April 19th – Monday 

    9:00 – 10:00 AM

                Registration and welcome breakfast 

    10:00 - 11:00 AM

                Opening section: RR Brentani: Research and teaching at a private hospital. 

    11:00 – 11:45 AM

                CH Brito-Cruz: FAPESP: Science and Technology in São Paulo. 

    11:45 – 12:30  PM

                R Pasqualini: Mapping molecular diversity by in vivo phage display. 

    12:30 – 2:30 PM


    2:30 – 3:15 PM

                W Arap: The human vascular mapping project. 

    3:15 – 4:00 PM

                R Drmanac: Medical genomics as the foundation of personalized disease prevention and treatments 

    4:00 – 4:20 PM

                Coffee break  

    4:20 – 5:05 PM

                R Seeley: How obesity went to our heads:  CNS regulation of energy balance 

    5:30 PM

                Welcome cocktail

    April 20th – Tuesday 

    9:00 – 9:45 AM

    W Cavenee: Improving cancer therapy targeted at mutant receptors 

    9:45 – 10:30 AM

                W Arap: Ligand-directed targeting and molecular imaging in translational medicine 

    10:30 – 10:50 AM

                Coffee break 

    10:50 – 11:35 AM

    R Drmanac: Understanding genetic and molecular basis of human diseases by sequencing one million human genomes 

    11:35 – 12:20  PM

                R Seeley: Gut-brain communication in obesity and diabetes

    12:20  – 1:40  PM

    1:40 – 3:20 PM

                Selected oral presentations

    - Sergio Iadevaia, MD Anderson Cancer Center, Houston, USA: Identification of optimal drug combinations targeting cellular networks: integrating phospho-proteomics and computational network analysis.

    - Avaduth Joshi, Johns Hopkins University, Baltimore, USA: Combined receptor tyrosine kinase inhibition of glioblastoma multiforme.

    - Alexandre JN Trindade, Universidade Técnica de Lisboa, Lisboa, Portugal: DLL4 inhibition therapy can accelerate wound healing by inducing functional neo-angiogenesis: a matter of dosage. 

    3:20 – 3:45 PM

                Coffee break 

    3:45 – 4:30 PM

                R Pasqualini: Vascular and lymphatic targeting: pre-clinical and clinical drug development updates 

    April 21st – Wednesday 

    9:00 -9:45 AM

                VR Martins: Prions: infectious mechanism and diseases 

    9:45 – 10:30 AM

    R Linden: The prion protein and the immune system - and the other way around 

    10:30 – 11:00 AM

                Coffee break 

    11:00 – 11:45 AM

    MA Prado: Yin and Yang of prion protein biology. 

    11:45 – 1:00  PM

    Selected oral presentations

    - Flavio HB Paiva, Robarts Res. Institute, London, Canada: Prion protein transduces signals after binding to laminin chain via metabrotopic glutamate receptors.

    - Bruno Costa da Silva, Ludwig Institute for Cancer Research, São Paulo, Brazil: Functional relevance of cellular prion protein (PrPC) and Hsp70/Hsp90 organizing protein (STI1/HOP) in colorectal and pancreatic tumors.

    - Ana Cristina R Magalhães, Robarts Res. Institute, London, Canada: CRF receptor 1 regulates anxiety behaviour via sensitization of 5-HT2 receptor signaling.

    - Maria Galli de Amorim, Philadelphia, USA: Modeling Rett syndrome with genetically modified mice. 

    1:00 – 2:00 PM


    2:00 – 2:45 PM

                VR Martins: Prion protein as a therapeutic target in cancer 

    2:45 – 3:30 PM

                R Linden: Neuroprotection by the transcription factor Max: Towards gene therapy for glaucoma 

    3:30 – 4:15 PM

                Coffee break 

    4:15 – 5:00 PM

    MA Prado: The use of genetically modified mice to model and understand human diseases. 


    April 22nd – Thursday 

    9:00 -9:45 AM

    A Bardelli: The genetic basis of response to EGFR targeted therapies in CRCs. 

    9:45 – 10:45 AM

    Oral Presentations

    - Rachid A. Karam, University of California San Diego, San Diego, USA: Coupling of RNA and protein quality controls in cancer.

    - Curtis Pickering, MD Anderson Cancer Center, Houston, USA: Profiling tongue squamous cell carcinoma to understand tumor formation, lymph node metastasis and drug resistance.

    - Gustavo de Campos Molina, Hospital AC Camargo, São Paulo, Brazil: Combination of an enzyme restriction and barcode method for transcriptional assessment in 454-platform. 

    10:45 – 11:15 AM

                Coffee break 

    11:15 – noon

    SR Rogatto: Integrative genomic and transcriptomic analysis of uterine leyomiomas 

    noon – 12:45 PM

    P Stankiewicz: Mechanisms of DNA rearrangements underlying genomic disorders 

    12:45- 1:45


    1:45 – 2:15

                Oral presentations:

    - Francine Blumental de Abreu, Hospital AC Camargo, São Paulo, Brazil: 3p12.3 and 7q36.3 harbor genes associated with hereditary breast and colorectal carcinomas.

    - Melanie Heney, Baylor College of Medicine, Houston, USA: Using a mouse copy number variation (CNV)-engineering system to study neurobehavioral and metabolic phenotypes in two genomic disorders SMS and PTLS 

    2:15 – 3:00 PM

                P Stankiewicz: Molecular mechanisms and clinical consequences of genomic disorders. 

    3:00 – 3:45 PM

    C Rosenberg : Advances in the diagnosis of mental retardation: from karyotyping to molecular cytogenetics. 

    3:45 – 4:15 PM

                Coffee break

    4:15 – 5:00 PM

                SR Rogatto: Copy number alterations in hereditary breast and colorectal cancer syndromes

    April 23rd – Friday 

    9:00 -9:45 AM

    A Bardelli: Isogenic mutant human cells: A new tool for personalized cancer medicine. 

    9:45 – 10:30 AM

                D Lyden: The switch between angiogenesis and vasculogenesis for tumor growth and metastases 

    10:30 – 10:50 AM

                Coffee break 

    10:50 – 11:35 AM

    D Lyden: The pre-metastatic niche: a permissive microenvironment for metastasis. 

    11:35  – 12:20 PM

    A Coutinho: Mechanisms of natural immunological tolerance: implications for cancer immunotherapy 

    12:20 - 1:05 PM

                A Coutinho: Integrating evolutionary layers of host protection: immunity and tolerance 

    Free Afternoon

    April 26th – Monday 

    9:45 – 10:30 AM

                O Podhajcer: Role of matricellular protein in cancer progression.           

    10:30 – 10:50 AM

                Coffee break 

    10:50 – 11:35 AM

                LP Kowalski: Oropharynx cancer: chemoradiation or surgery? 

    11:35 – 12:20 PM

                A Lopes: Penile carcinoma, clinical aspects, treatment and prognostic factors 

    12:20 – 1:30  PM


    1:30 – 2:30 PM

    Oral Presentations

    - Di Ai, University of Texas, Houston, USA: Cardiomyocyte PDGFR-b signaling is an essential component of the mouse cardiac response to load-induced stress.

    - Márcio L. Acêncio, UNESP, Botucatu, Brazil: In silico network-based discovery of candidate RB-E2F axis-independent signaling pathways involved in the cell-matrix adhesion-mediated control of G1/S cell cycle transition.

    - Carla Abdo Brohem, Universidade de São Paulo, São Paulo, Brazil: Mechanism of action of 4-nerolidylcathecol: induction of apoptosis via ROS accumulation and inhibition of invasion in melanoma and skin reconstructs model.

    - Mauro SG Pavão, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil: oversulfated dermatan sulfate from ascidians, but not its mammalian counterpart, inhibits p-selectin in vitro and metastasis in vivo.

     2:30 – 3:15 PM

                J Kobarg: The role of Nek family kinases in cell cycle progression and DNA damage responses. 

    3:15 – 3:45 PM

    Coffee break 

    3:45 – 4:30 PM

                S Rehen: Embryonic and pluripotent stem cells as tools for studying neurogenesis 

    4:30 – 5:15 PM

                R Chammas: Functional significance of carbohydrate-dependent tumor associated antigens 

    5:15 – 6:00 PM

    FA Soares: Morphological aspects of the EMT phenomenon

    April 27th - Tuesday 

    9:00 -9:45 AM

    Bettina Weigelin, Nijmegen, Netherlands: Dynamic imaging of the tumor microenvironment: impact on invasion and CTL effector function.

    9:45 – 10:30 AM

    J Kobarg: The human microtubule transport adaptor protein FEZ1 is involved in the formation of “flower-like” nuclei. 

    10:30 – 10:50 AM

                Coffee break 

    10:50 – 11:35 AM

                S Rehen: Neural differentiation is followed by aneuploidy in embryonic and induced pluripotent cells 

    11:35 – 12:50 PM

                Oral presentations

    - Luciane Fragel Madeira, Universidade Federal Fluminense, Rio de Janeiro, Brazil: A check-point induced by platelet activating factor arrests retinal progenitors at the S/G2 cell cycle transition.

    - Patrícia M. Machado, Instituto Português de Oncologia de Lisboa, Lisboa, Portugal: BRCA1/2 genetic screening in Portuguese high-risk breast/ovarian cancer families.

    - Alisson M Burton, MD Anderson Cancer Center, Houston, USA: Health and life-style behaviors among persons at risk for Lynch syndrome.

    - Edenir Inez Palmero, Hospital de Câncer de Barretos, Barretos, Brazil: TP53, PIN3 and MDM2 SNP309 polymorphism as genetic modifiers in the Li-Fraumeni syndrome: impact on age at first diagnosis.

    - Sofia Braga, Instituto Gulbenkian de Ciência, Oeiras, Portugal: Heterogeneity of triple negative breast cancer.

    12:50 – 1:50 PM


    1:50 – 2:35 PM

                P Hainaut: TP53 suppressor gene: from genomics to clinical applications. 

    2:35 – 3:20 PM

    MI Achatz: Managing families with inherited cancer; High prevalence of R337H mutation in Brazilian LFS/LFL families. 

    3:20 – 3:50 PM

                Coffee break 

    3:50 – 4:35 PM

                P Ashton-Prolla: Genetic counseling in inherited predisposition cancer syndromes 

    4:35 – 5:20 PM

                D Malkin: The role of DNA copy number variation in childhood cancer susceptibility. 

    5:20 – 6:05 PM

                FA Soares: Tumor differentiation – phenotypic/genotypic relationships 


    April 28th – Wednesday (new) 

    9:30 – 10:15 AM

                O Podhajcer: Oncolytic vectors in cancer therapy 

    10:15 – 10:30 AM

    Coffee break 

    10:30 – 11:15 AM

    R Tuder: Interplay between alveolar cell apoptosis, oxidative stress, and senescence in cigarette smoke-induced pulmonary diseases 

    11:15 – 12:15 PM    Oral presentations

    - Cintia Yoko Morioka, Toyama Medical and Pharmaceutical University, Toyama, Japan. Anti-sense oligonucleotide matching k-ras gene in hamster pancreatic cancer model in-vitro and in-vivo – Is it possible?

    - Pedro MP Coelho, Depto de Anatomia, Univ. Federal do Rio de Janeiro, Rio de Janeiro, Brazil. Cell therapy in a rodent model of neonatal hypoxic-ischemic encephalopathy.

    - Agda Karina Eterovic, University of Texas Health Science Center, Houston, USA. Mediators of glioblastoma resistance and invasion during anti-VEGF therapy.

    - Valerie LeBleu, Harvard Medical School Boston, USA. Disruption of tumor angiogenesis leads to increased metastasis due to HIF1a/CD44/p38 MAP kinase mediated epithelial to mesenchymal transition. 

    12:15 – 1:30  PM


    1:30 – 2:15 PM

                R Kalluri: Systemic angiogenesis balance and tumor microenvironment. 

    2:15 – 3:00 PM

    R Tuder: Abnormal angiogenesis and disregulated growth of pulmonary endothelial cells in pulmonary hypertension. 

    3:00 – 3:30 PM

    Coffee break 

    3:30 – 4:15 PM

    R Giordano: Development of anti-angiogenic compounds: Phage-display and the angiogenic retina as a model 

    4:15 – 5:00 PM

                I Izquierdo: Memory consolidation 

    5:00 – 5:45 PM

                DI Smith: Developing the infrastructure for next-generation DNA sequencing at the Mayo clinic 

    April 29th – Thursday 

    9:00 -9:45 AM

    R Costa: Neural mechanisms of action learning: from intent to habit 

    9:45 – 10:30 AM

                Z Mainen: Sensory perception: Lessons from the olfactory system of the rat 

    10:30 – 11:00 AM

                Coffee break 

    11:00 – 12:15 AM

                Oral presentations

    - Angela A. Fachel, Universidade de Sao Paulo, Sao Paulo, Brazil.  Long intronic non-coding RNA signatures of malignancy and survival outcome in clear cell renal carcinoma.

    - Barbara Pereira de Melo, Hospital AC Camargo, Sao Paulo, Brazil. No-match ORESTES explored as non-coding tumor markers.

    - Gustavo J. Rodrigues, Baylor College of Medicine, Houston, USA. Allosteric communication within the dopamine D2 receptor: evolution-guided retooling receptor activation specificity.

    - Frederico R. Ferreira, Faculdade de Medicina, Universidade de Sao Paulo, Ribeirao Preto, Brazil. Effects of treatment with 7-nitroindazole (7NI), a neuronal NO synthase inhibitor, or imipramine on protein and gene expression in the hippocampus of rats submitted to the forced swimming test.

    - Janine Inez Rossato, Instituto do Cérebro, PUC-RS, Porto Alegre, Brazil. On the reconsolidation of extinction memory. 

    12:15 – 1:30 PM


    1:30 – 2:15  PM

                V Moura-Neto: Cross-talk between parenchyma and glial cells: highlights in brain tumors 

    2:15 – 3:00 PM

                I Izquierdo: Memory persistence I 

    3:00 – 3:45 PM

                I Izquierdo: Memory persistence II 

    3:45 – 4:15 PM

                Coffee break 

    4:15 – 5:00 PM

                R Costa: Generating action sequences 

    5:00 – 5:45 PM

                Z Mainen: Decision-making: Executing and monitoring decisions under uncertainty 

    5:45 – 6:45 PM

                Diego Olego: Technical innovations in oncology