Advances in Molecular Oncology: Translating Molecular Biology into Cancer Treatment


A ESPCA - Advances in Molecular Oncology: Translating Molecular Biology into Cancer Treatment (2013) foi organizada pela FMUSP/ICESP, com coordenação dos Professores Maria Aparecida Nagai, Roger Chammas, Lois Mulligan e Robert Gilles, e apoiada pela FAPESP.

A escola contou com a participação de 33 palestrantes nacionais e 28 estrangeiros, reconhecidos internacionalmente na área de pesquisa em oncologia, com programa multidisciplinar, combinando sessões plenárias sobre temas abrangentes na área de câncer, sessões paralelas e minicursos abordando de conceitos básicos à pesquisa translacional em câncer.

Foram abordados avanços atuais abrangendo aspectos da genética e epigenética do câncer, epidemiologia molecular, transição epitélio mesênquima, microambiente tumoral, morte celular e mecanismos de metástase da pesquisa básica à translacional.

O programa científico inclui também sessões de pôster para ampliar a participação dos jovens investigadores e criar oportunidades de interação informal e formação de redes de trabalho.

Foram selecionados 60 estudantes e jovens pesquisadores de instituições estrangeiras e 62 de instituições nacionais.

A ESPCA reuniu pesquisadores chave da área de pesquisa em Oncologia Molecular e Translacional e estudantes e jovens pesquisadores procurando criar um fórum de discussão e fomentando colaborações nessa crescente, mas ainda carente área de pesquisa em oncologia.

PAÍSES REPRESENTADOS:
Palestrantes de Portugal, Espanha, Grécia, Irlanda, Estados Unidos, Canadá, Israel e Coreia do Sul.
Estudantes de Argentina, Uruguai, Espanha, Itália, Portugal, Polônia, Alemanha, Irlanda, Coréia, Estados Unidos, Canadá e África do Sul.

  • Intituição

    Faculdade de Medicina / Universidade de São Paulo

  • Área de conhecimento

    Medicina

  • Pesquisador Responsável

    Maria Aparecida Nagai

  • Nº do Processo FAPESP

    2012/50309-5

  • Período

    03/02/2013 a 08/02/2013

  • Inscrições

    Encerradas

  • Site

  • Cidade

    São Paulo

  • Palavras-chave

    Pesquisa translacional, Microambiente tumoral, Alvos terapêuticos, Oncologia molecular, Biomarcadores, Câncer

  • Programa Ocultar

     

    Day

    Time

     

    Feb 2nd

    14:00 – 17:30

    Check in, credentials, material distribution

    Sunday, February 3rd        FMUSP  Theater

    Plenary sessions          9:00  -  18:30

    07:30 – 08:45

    Check in, credentials, material distribution

    09:00 – 09:20

    Opening Ceremony and Welcoming Remarks

    Prof. Dr. José Otávio Auler

    Director in Office of Medical School, University of São Paulo (FMUSP)

    Prof Dr Giovanni Guido Cerri

    Director of Medical School, University of São Paulo (FMUSP)

    Secretary of Health of the State of São Paulo

    Prof Dr Marco Antônio Zago

    Pro-Chancellor of Research of the University of São Paulo (USP)

    Prof Dr José Eluf Neto

    Executive Director of the Laboratories of Medical Investigation  (LIMs)

    Prof Dr Flavio Fava de Moraes

    Director of Medical School Foundation  (FFM)

    Prof Dr Carlos Henrique de Brito Cruz

    Scientific Director of Foundation for Research Support of São Paulo (FAPESP)

    Prof Dr Paulo Hoff

    Head of Clinical Oncology- Medical School, University of São Paulo and ICESP Clinical Diretor

    Prof Dr Roger Chammas

    Head of Basic Oncology- Medical School, University of São Paulo (FMUSP)

    Prof Dra Maria A  Nagai

    Associate Professor, Medical School, University of São Paulo (FMUSP)

    09:30 – 09:40

    Paulo Hoff  – Welcome note

    Head of Clinical Oncology- Medical School, University of São Paulo and ICESP Clinical Diretor, São Paulo, Brazil

    09:40 – 10:20

    Carlos Henrique de Brito Cruz

    Diretor científico FAPESP, São Paulo, Brazil

    10:20 – 10:50

    Marco Antônio Zago

    Pro-Chancellor of Research of the University of São Paulo (USP), São Paulo, Brazil

    10:50 – 11:20

    Coffee break

    11:20 – 12:20

    Opening conference

    Molecular Imaging and the tumor microenvironment

    Robert Gillies, Moffitt Cancer Center, Tampa, USA

    12:20 – 14:00 

    Lunch

     

    Chairs persons: José Eluf Neto

    14:00 – 15:00

    Molecular and immunohistochemical markers of gastric carcinoma differentiation and progression.

    Maria de Fátima MH Carneiro – IPATIMUP, Porto, Portugal

    15:00 – 16:00

     

    Triple-Negative Breast Cancer: an example for translational cancer research

    Fernando Schmitt, IPATMUP, Porto, Portugal

    16:00 – 16:30

    Coffee break

    16:30 – 17:30

    Hepatocellular carcinoma – advances in the integration of morphological and molecular aspects, towards a new classification useful for clinical decisions

    Park YN, Yonsei University College of Medicine, Seoul, Korea

    17:30 – 18:30

    Role of biomarkers in cancer detection and patient management

    Michael J Duffy, School of Medicine & Medical Science, St Vincents University Hospital, Dublin, Ireland

    19:00 – 21:00 (ICESP)

    Welcome Cocktail

     

    Day

    Time

     

    Monday, February 4th                            ICESP 

    Mini-courses

    8:00 – 8:45

    Room A

    MC1 - Immunology for the non-immunologist

    José Alexandre Barbuto, Biomedical Sciences Institute, University of São Paulo,  São Paulo, Brazil

    Room B

    MC2 - Principles of Clinical Research in Oncology

    Rachel Simoes Pimenta Riechelmann, ICESP, São Paulo, Brazil

    Room C

    MC3 - 3D culture and mammary gland tumour engraftment as models for studying the biology and therapeutics

    Bruce Elliott, Queen’s University, Canada

    Concurrent sessions -  Molecular biology of cancer: an update          09:00 – 12:30

    Session 1: Breast cancer

    Room A

    Chair persons: M Mitzi Brentani and Maria A Nagai

    09:00 – 09:50

    Introduction to mammary gland biology and breast cancer

    Paraic Kenny,Albert Einstein College of Medicine, Bronx, NY,USA

    09:50 – 10:30

     

    The cancer Genome Atlas: Comprehensive  molecular portraits of human tumros

    Katherine Hoadley Research Associated, Lineberger Comprehensive Cancer Center, Univ N Carolina, USA

    10:30 – 11:00

    Coffee break

    11:00 – 11:30

    Transcriptional profile as prognostic and predictive factor in breast cancer

    Maria A K Folgueira, Medical School, University of São Paulo, São Paulo, Brazil

    11:30 – 12:00

     

    Molecular alterations mediated by BRCA1 mutations in triple-negative breast tumors

    Dirce M Carraro, A C Camargo Hospital, São Paulo, Brazil

    12:00 – 12:30

     

    Prognostic Significance of Citokeratin Markers in Breast cancer – A Meta Analysis

    Vivian Barak, Associate Professor in Oncology, Hebrew University, Jerusalem, Israel

    Session 2: Anogenital tumors

    Room B

    Chairs persons: Luisa L Villa and Anna R. Giuliano

    09:00 – 09:50

    Epidemiology of anogenital cancers.

    Anna R. Giuliano, H. Lee Moffitt Cancer & Center Research Institute, Tampa, USA

    09:50 – 10:30

     

    Carcinogenic role of HPV in anogenital tumors

    Enrique Boccardo, Biomedical Sciences Institute, University of São Paulo,  São Paulo, Brazil

    10:30 – 11:00

    Coffee break

    11:00 – 11:30

    Immune responses to HPV infection and cancer.

    Ligia A. Pinto, National cancer Institute, Maryland, USA

    11:30 – 12:00

    HPV vaccination for anogenital cancer prevention

    Luisa Lina Villa, Medical School, University of São Paulo, São Paulo, Brazil-ICESP

    12:00 – 12:30

    Anogenital Cancer Treatment

    Edmund Chada Baracat, Medical School, University of São Paulo, São Paulo, Brazil

     

    12:30 – 14:00

    Lunch and Poster Session A

     

    Day

    Time

     

    Monday, February 4th                            ICESP 

    Concurrent sessions -  Molecular biology of cancer: an update              14:00 – 17:00

    Room A

    14:00 – 14:50

     

    Chairs persons: Roger Chammas

    Epidemiology in the "omics" era: will the leaves hide the forest?

    Núria Malats, CNIO, Madrid, Spain

    Session 3: Gastric cancer

    Room A

    Chairs persons: Ulysses Ribeiro Jr and Ivan Cecconello

    14:50 – 15:30

     

    Familial gastric cancer: overview and guidelines for management.

    Osmar K. Yagi – Clinics Hospital-Medical School, University of São Paulo, São Paulo, Brazil

    15:30 – 16:00

    Gastric stump carcinoma. An experimental model for gastric carcinogenesis?

    Adriana Vaz Safatle Ribeiro – Clinical Hospital-Medical School, University of São Paulo and ICESP, São Paulo, Brazil

    16:00 – 16:30

     

    Coffee break

    16:30 – 17:00

     

    Targeted therapy in gastric cancer.

    Renata de Almeida Coudry – Cancer Institute São of Paulo State ICESP

    Session 4: Hepatocellular and pancreatic tumors

     

    Room B

    Chairs persons: Venancio Alves and Young N Park 

    14:00 – 14:50

     

    Morphological and Molecular characterization of the vascular features of hepatocellular carcinoma from Dysplasia to Advanced Neoplasia
    Annette Gouw, University Medical Center Groningen, Groningen, Netherlands

    14:50 – 15:30

     

    Hypoxia and Hepatocarcinogenesis, emphasizing the putative role
    of monocarboxylate transporters

    Venancio Alves, Medical School, University of São Paulo/ICESP, São Paulo, Brazil

    15:30 – 16:00

     

    A fibrous stromal component in hepatocellular carcinoma reveals a cholangiocarcinoma-like gene expression trait and EMT.
    Young N Park, Yonsei University College of Medicine Seodaemun, Seoul, Korea.

    16:00 – 16:30

     

    Coffee break

    16:30 – 17:00

     

    Cholangiocarcinoma and variants – from hilar/large bile duct carcinomas to peripheral ductular carcinomas and hepatocholangiocarcinomas

    Evandro S Mello, Medical School, University of São Paulo, São Paulo, Brazil

    Room A

    Chairs person: Gilberto de Castro

    17:00 -17:30

    The PrimerBank database of human and mouse primer pairs for gene expression, detection and quantification

    Athanasia Spandidos - Medical School, University of Athens, Greece and Harvard Medical School, Boston, USA

    Room B

    Chairs person: Nadja Cristhina de Souza Pinto

    17:00 -17:30

    DNA repair and Cancer Therapy

    Carlos FM Menck - Biomedical Sciences Institute, University of São Paulo, São Paulo, Brazil

    Conference

    17:30 – 18:30

    Chair person: Maria A Nagai

    Ras oncogene and human cancer

    Demetrios Spandidos, Medical School, University of Crete, Crete, Greece

     

     

    Day

    Time

     

    Tuesday, February 5th                                    ICESP

    Mini-courses

    8:00 – 8:45

    Room A

    MC1 - Immunology for the non-immunologist

    José Alexandre Barbuto, Biomedical Sciences Institute, University of São Paulo, São Paulo, Brazil

    Room B

    MC2 - Principles of Clinical Research in Oncology

    Rachel Simoes Pimenta Riechelmann, ICESP, São Paulo, Brazil

    Room C

    MC3- 3D culture and mammary gland tumour engraftment as models for studying the biology and therapeutics

    Bruce Elliott, Queen’s University, Canada

    Concurrent sessions -  Molecular biology of cancer: an update     09:00 – 12:30

    Session 5: Head and Neck and Lung Cancer

    Room A

    Chairs persons: Gilberto de Castro and André Lopes Carvalho

    09:00 – 09:50

    Predictive lung tumor response to targeted therapies

    MarileilaVarella-Garcia, School of Medicine, Division of Medical Oncology, University of Colorado Denver, Denver, USA

    09:50 – 10:30

    miRNAs as gene regulators in thyroid cancer

    Edna Teruko Kimura Biomedical Sciences Institute, University of São Paulo, São Paulo, Brazil

    10:30 – 11:00

    Coffee break

    11:00 – 11:30

    Hypermethylation: its role in upper aerodigestive tract carcinogenesis and implications in clinical practice.

    André Lopes Carvalho, Cancer Hospital of Barretos, Barretos,  Brazil

    11:30 – 12:00

    Molecular epidemiology of lung câncer

    Carlos Gil Ferreira, National Institute of Cancer, Rio de Janeiro, Brazil

    12:00 – 12:30

    Cancer-stromal interactions in upper aerodigestive cancers

    Eloiza Helena Tajara da Silva, State of São Paulo University, São José do Rio Preto, Brazil

    Session 6: Hematopoietic tumors

    Room B

    Chairs persons: Eduardo Rego and Robert Gallagher

    09:00 – 09:50

     

    Molecular heterogeneity considerations in leukemia therapy: lessons from acute promyelocytic leukemia

    Robert Gallagher, Montefiore Medical Center, Albert Einstein Cancer Center, USA

    09:50 – 10:30

     

    Mitocans as anti-leukemia agent.

    Eduardo Rego, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil

    10:30 – 11:00

     

    Coffee break

    11:00 – 11:30

    Telomere length regulation in hematological malignancies

    Rodrigo Calado, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil

    11:30 – 12:00

     

    Bone marrow malignancies

    Sara T. O. Saad, University of Campinas, Campinas, Brazil

    12:00 – 12:30

     

    Tumor Antigens and T-Cell Subpolutations: Possible targets for immunotherapy in  lymphoproliferative disorder.

    Gisele Colleoni, Federal University of São Paulo, São Paulo, Brazil

     

     

    12:30 – 14:00

    Lunch and Poster Session B

     

    Day

    Time

     

    Tuesday, February 5th        ICESP

    Concurrent sessions -  Molecular biology of cancer: an update     14:00 – 17:30

     

    Room A

    Chairs persons: Luisa Lina Villa

    14:00 – 15:00

    MicroRNAs in the progression of prostate cancer

    Anindya Dutta, Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, USA

    Session 7: Prostate cancer

    Room A

    Chairs persons: Miguel Srougi and Katia Moreira Leite

    15:00 – 15:30

     

    Epigenetics in prostate cancer: biologic and clinical relevance.

    Katia Moreira Leite, Medical School, University of São Paulo, São Paulo, Brazil

    15:30 – 16:00

     

    Perspectives of Long Non-Coding RNAs in Cancer Diagnostics

    Eduardo M Reis, Departamento de Bioquímica Instituto de Química - Universidade de São Paulo

    16:00 – 16:30

    Coffee break

    16:30 – 17:00

    Tumor banks: the cornerstone of basic research in urology.

    Sabrina Reis, Medical School, University of São Paulo, São Paulo, Brazil

    17:00 – 17:30

     

    Translational research in bladder cancer: from molecular pathogenesis to useful tissue biomarkers.

    Alberto Azoubel Antunes, Medical School, University of São Paulo, São Paulo, Brazil

    Session 8: Central nervous system tumors

    Room B

    Chairs persons: Suely K Marie and Gregory Riggins

    14:00 – 14:50

    Preclinical development for glioblastoma: Bridging the gap between basic and clinical science

    Gregory Riggins, Ludwig Collaborative, Baltimore, USA

    14:50 – 15:30

     

    New and old approaches to search for anti-tumor targets of clinical relevance

    Mari Cleide Sogayar, NUCEL-Cell and Molecular Therapy Center, University of São Paulo, São Paulo, Brazil

    15:30 – 16:00

     

    Central nervous system melatonin production and cancer

    Regina Pekelmann Markus, Institute of Bioscience, University of São Paulo, São Paulo, Brazil

    16:00 – 16:30

    Coffee break

    16:30 – 17:00

    Proteomic analysis to search for new therapeutic targets in glioma

    Jose Cesar Rosa, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil

    17:00 – 17:30

     

    Stem cell markers of medulloblastoma as therapeutic targets

    Carlos Gilberto Carlotti, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil

    Conference

    17:30 – 18:30

    Chair person- Roger Chammas

    New mouse models for in vivo imaging of tumor metastasis: application to gene discovery and drug response in melanoma

    María S Soengas, Centro Nacional de Investigaciones Oncológicas, Madrid, Spain

     

     

    Day

    Time

     

    Wednesday, February 6th                                    ICESP

    Mini-courses

    8:00 – 8:45

    Room A

    MC1 - Immunology for the non-immunologist

    José Alexandre Barbuto, Biomedical Sciences Institute, University of São Paulo, São Paulo, Brazil

    Room B

    MC2 - Principles of Clinical Research in Oncology

    Rachel Simoes Pimenta Riechelmann, ICESP, São Paulo, Brazil

    Room C

    MC3 - 3D culture and mammary gland tumour engraftment as models for studying the biology and therapeutics

    Bruce Elliott, Queen’s University, Canada

    Plenary sessions

    9:00 – 12:50   

     

    Chairs persons: Paulo H Saldiva and Francisco X Real

    09:00 – 9:50

    Environment and cancer

    Paulo H Saldiva, Medical School, University of São Paulo, São Paulo, Brazil

    9:50 – 10:30

     

    Apoptosis: Extracellular Effects of the Tumor Suppressor Par-4

    Vivek Rangnekar, Department of Radiation Medicine, University of Kentucky, Lexington, USA

    10:30 – 11:10

    Novel Therapeutic Strategies for Recurrent Prostate Cancer

    Anna Ferrari, NYU Cancer Institute, New York, USA

    11:10 – 11:30

    Coffee break

    11:30 – 12:10

    Abnormal O-glycosylation in cancer: from biology to clinical applications

    Eduardo Osinaga, Faculdad de Medicina, Universidad de la Republica, Montevideo, Uruguay

    12:10 – 12:50

    Molecular pathways leading to pancreatic cancer

    Francisco X. Real, CNIO, Madrid, Spain

     

    12:50 – 14:00

    Lunch

    Oral presentation – selected papers

    14:00 – 17:00

    14:00 – 14:15

    Acetyleugenol nanocapsules impairs in vivo melanoma growth and impairs melanoma cells proliferation and adhesion in vitro. Drewes, C.C., FCF/USP, Brazil

    14:15 – 14:30

    Defining the GRB7 interactome in triple-negative breast cancer. Calvo, V., Albert Einstein College of Medicine, USA

    14:30 – 14:45

    Use of γH2aX and other biomarkers to quantify distribution of drug activity in solid tumors. Saggar, J.K., University of Toronto, Canada

    14:45 -  15:00

    The positive is inside the negative: HER2 negative tumors can present a HER2 positive phenotype, with positive intracytoplasmatic domain and phosphorylated PI3- kinase expression. Panis, C., Instituto Nacional do Câncer, Brazil

    15:00 – 15:15

    Expression, activity, and inducibility of pregnane-x- receptor and its role in multidrug-resistance in head and neck squamous cell carcinoma. Rigalli, J.P., University of Heidelberg, Germany

    15:15 – 15:45

    Coffee break

    15:45 – 16:00

    Iodine maintains Smad4 levels and TGFB responsiveness in BRAF-activated thyroid cells through miR-19 ablation. Fuziwara, C.S., ICb/USP, Brazil

    16:00 – 16:15

    NOSH-aspirin (NBS-1120) inhibits breast cancer cell growth in vitro and in vivo: An effect modulated through reactive oxygen species and independent of the ER status. Chattopadhyay, M., City University of New York Medical School, USA

    16:15 – 16:30

    Effect of the CIGB-300 synthetic peptide in the modulation of signaling pathways involved with malignant progression of human and murine lung tumors. Cirigliano, S.M., Instituto de Oncología "A. H. Roffo", Argentina

    16:30 -  16:45

    Genome wide association study of Hodgkin’s lymphoma.  Silva Filho, M.I., German Cancer Research Center, Germany

    16:45 – 17:00

    Zeolites as suitable Drug Delivery Systems for anticancer drugs in in vitro models of colorectal carcinoma. Amorim, R., University of Minho, Portugal

    Conference

    17:00 – 18:00

    Chair person: Roger Chammas

    Tumor heterogeneity

    Francisco X. Real , CNIO, Madrid, Spain

    Day

    Time

     

    Thursday, February 7th      FMUSP Theater

    Plenary sessions    

    Inherited tumors

    8:00 – 12:30

     

     

    Chair persons: Lois M Mulligan and  Sergio A Toledo

    08:00 – 09:00

    DICER1 mutations result in a surprising array of phenotypes

    William D Foulkes, McGill University, Montreal, Canada

    09:00 – 09:40

    Established and proposed ovarian cancer susceptibility genes

    Patricia Tonin, McGill University, Montreal, Canada

    09:40 – 10:00

    Coffee break

    10:00 – 10:40

    Mechanisms of RET Receptor Dysfunction

    Lois M Mulligan, Queen’s University, Kingston, Canada

    10:40 – 11:20

    Management for multiple endrocrine neoplasia typ 2: impact of the RET proto-oncogene analysis

    Sergio A Toledo, Medical School, University of São Paulo, São Paulo, Brazil

    11:20 – 12:00

    The genetic heterogeneity of pheochromocytomas

    Patricia Dahia, San Antonio Cancer Institute, San Antônio, Texas, USA

     

    12:00 – 14:00 

    Lunch

    Advanced Technologies and cancer therapy

    14:00 – 18:30

     

     

    Chair persons: Roger Chammas and Francisco Real

    14:00 – 15:00

    Advances in Nanomedicine and Nanotoxicology: Manipulation of Nanomaterials for Diagnostic and Therapy

    Valtencir Zucolotto Institute of Phisic, University of São Paulo, São Carlos, Brazil

    15:00 – 16:00

     

    Targeted nanoparticles for non-invasive hyperthermia in malignant disease

    Steven A Curley, MD Anderson Cancer Center in Houston, Texas, USA

    16:00 – 16:30

    Coffee break

    16:30 – 17:30

    Identification of subtype-specific breast cancer targets using 3D 
    culture models

    Paraic Kenny, Albert Einstein College of Medicine, New York,USA

    17:30 – 18:30

    Reverse engineering multiple myeloma: putting numbers to faces

    Ariosto Silva, Moffitt Cancer Center, Tampa, FL, USA 

      

    Day

    Time

     

    Friday, February 8th

     

    FMUSP Theater  

    Plenary sessions      08:30 – 12:30

     

    Chair persons: Roger Chammas and Maria A Nagai

    08:30 -09:30

    The War on Cancer: Are we winning?

    Michael J Duffy, School of Medicine & Medical Science, St Vincents University Hospital, Dublin, Ireland

     

    09:30 – 10:30

    Biomarkers for prediction of Metastasis in Melanoma

    Vivian Barak, Associate Professor in Oncology, Hebrew University, Jerusalem, Israel

    10:30 – 11:00

     

    Coffee break

     

     

    11:00 – 11:45

    Publishing in Biomedical Sciences.

    Demetrios Spandidos, Medical School, University of Crete, Crete, Greece

    12:00 – 12:30

    Closing Remarks and Departure

    Roger Chammas, Medical School, University of São Paulo, São Paulo, Brazil

    Vivek Rangnekar, Department of Radiation Medicine, University of Kentucky, Lexington, USA

    Michael J Duffy, School of Medicine & Medical Science, St Vincents University Hospital, Dublin, Ireland

    Supervised visit

    14:30  – 17:30

     

    Cancer Institute of São Paulo State 

    Medical School of the University of São Paulo 

    Center of Nuclear Medicine